Jewish musical prodigy Lisa Jura has a wonderful life in Vienna. But when the Nazis start closing in on the city, life changes irreversibly. Although he has three daughters, Lisa's father is only able to secure one berth on the Kindertransport. The family decides to send Lisa to London so that she may pursue her dreams of a career as a concert pianist. Separated from her beloved family, Lisa bravely endures the trip and a disastrous posting outside London before finding her way to the Willesden Lane Orphanage.
It is in this orphanage that Lisa's story truly comes to life. Her music inspires the other orphanage children, and they, in turn, cheer her on in her efforts to make good on her promise to her family to realize her musical potential. Through hard work and sheer pluck, Lisa wins a scholarship to study piano at the Royal Academy. As she supports herself and studies, she makes a new life for herself and dreams of reconnecting with the family she was forced to leave behind. The resulting tale delivers a message of the power of music to uplift the human spirit and to grant the individual soul endurance, patience, and peace.